Effect of leucas aspera on experimental inflammation and mast cell degranulation.

The aqueous and alcoholic extracts of Leucas aspera were investigated for their action on experimental inflammation and on mast cell degranuatlion. Both the extracts exhibited significant antiinflammatory action of acute and chronic inflammation. The mast cell drgranulation induced by proprancolol and Carbachol was effectively prevented by pretreatment with Leucas aspera extracts.

Gossypin-induced analgesia in mice.

A flavonoid, gossypin, was evaluated for its analgesic action by using acetic acid-induced writhing in mice and was compared with morphine. Gossypin inhibited writhing in a dose-dependent manner. This action was antagonised by naloxone.