Publications by authors named "P T Sager"
Background: The objective of this report is to present a case of two cervical spine artificial discs (Bryan Cervical Disk) that completely disappeared within 6 months as a result of a high-energy trauma more than 10 years after the initial surgery. Implant dislocation is a known complication in artificial cervical disc replacement. However, this report presents the case of an exceptional migration path with esophageal ingrowth and rectal excretion, not only for one artificial disc but for two at different times It highlights the need for long-term follow-up examinations after artificial cervical disc arthroplasty (ACDA).
View Article and Find Full Text PDFThe human voltage-gated sodium channel Na1.5 (hNa1.5/SCN5A) plays a critical role in the initiation and propagation of action potentials in cardiac myocytes, and its modulation by various drugs has significant implications for cardiac safety.
View Article and Find Full Text PDFArticle Synopsis
- Goal of Study
- : Researchers evaluated the safety and efficacy of MP1032, a host-directed therapy, in hospitalized patients suffering from moderate to severe COVID-19, as current vaccines and treatments have limitations due to new variants and uneven vaccine distribution.
- Study Design
- : A Phase IIa randomized double-blind placebo-controlled trial involved 132 patients across six countries, comparing MP1032 plus standard care against a placebo and standard care over 28 days, primarily assessing disease progression on day 14.
- Results
- : The findings indicated no significant difference in disease progression between the groups on days 14 and 28, with very few patients vaccinated, highlighting potential challenges in establishing the effectiveness of MP1032.*