Publications by authors named "P T Pekkarinen"
Introduction: Post-resuscitation care of cardiac arrest patients may be complicated by systemic inflammation elicited in response to whole-body ischaemia-reperfusion injury. We assessed the association between early WBC with one-year mortality in a large, unselected population of cardiac arrest patients.
Methods: We collected a retrospective multicentre cohort of ICU-treated CA patients from the Finnish national ICU registry.
Article Synopsis
- The study aimed to establish clear cutoff points for low, intermediate, and high doses of norepinephrine (noradrenaline), a key vasopressor in intensive care, to better assess patient mortality linked to cardiovascular support.
- Researchers analyzed data from over 8,000 ICU patients in Finland and validated the findings with a larger dataset from the U.S., focusing on the highest norepinephrine doses administered within the first 24 hours.
- The identified dose ranges were low (<0.2 μg/kg/min), intermediate (0.2-0.4 μg/kg/min), and high (>0.4 μg/kg/min), with increasing mortality rates correlating with higher doses, demonstrating a significant relationship between norepine
Background: In refractory out-of-hospital cardiac arrest, the patient is commonly transported to hospital with mechanical continuous chest compressions (CCC). Limited data are available on the optimal ventilation strategy. Accordingly, we compared arterial oxygenation and haemodynamics during manual asynchronous continuous ventilation and compressions with a 30:2 compression-to-ventilation ratio together with the use of 10 cmHO positive end-expiratory pressure (PEEP).
View Article and Find Full Text PDFArticle Synopsis
- * Researchers created PeptiVAX, a novel vaccine platform using PeptiCRAd technology, which targets broader T-cell responses by focusing on conserved regions across coronaviruses instead of just the SPIKE protein.
- * Initial tests in human immune cells and mice showed that PeptiVAX effectively stimulated specific T-cell responses, suggesting it could be a fast and flexible solution for enhancing vaccine efficacy against SARS-CoV-2.