Publications by authors named "P T Massa"
Background And Hypothesis: Angiogenesis triggered by inflammation increases BBB permeability and facilitates macrophage transmigration. In the midbrain, we have discovered molecular alterations related to the blood-brain barrier (BBB), including endothelial cell changes associated with macrophage diapedesis, in neuroinflammatory schizophrenia and bipolar disorder, but changes in angiogenesis are yet to be reported. Hypothesis: We expected to discover molecular evidence of altered angiogenesis in the midbrain in individuals with schizophrenia and bipolar disorder compared to controls, with these changes more evident in "high" inflammation schizophrenia as compared to "low" inflammation.
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- The study investigates the incidence, mechanisms, and predictors of sudden death (SD) in patients with cardiac amyloidosis, a serious heart condition.
- It analyzed data from 784 patients with either ATTR or AL cardiac amyloidosis, finding that SD is more common in AL patients compared to those with ATTR.
- Key risk factors for SD include previous pacemaker implantation for ATTR patients and the use of beta-blockers and advanced heart failure symptoms (NYHA III-IV) for AL patients.
Article Synopsis
- The study aims to compare the social and HIV vulnerability of adolescents from sexual minorities who started pre-exposure prophylaxis (PrEP) at community-based organizations (COs) versus a traditional health service in São Paulo.
- It found that adolescents at COs had quicker access to PrEP and generally faced lower housing development indicators, indicating higher social vulnerability.
- Despite being more socially vulnerable, adolescents from COs did not exhibit higher-risk sexual behaviors compared to those using traditional services, suggesting that COs improve access without increasing risk.
Article Synopsis
- - The study aimed to explore how transsexual, travesti women, and non-binary or gender-fluid individuals (TGWT+) perceive and experience health services concerning pre-exposure prophylaxis (PrEP) before and during the COVID-19 pandemic.
- - Through 45 semi-structured interviews in São Paulo, researchers found that TGWT+ individuals redefined their struggles and health care practices, highlighting the ongoing challenges posed by both the HIV epidemic and the pandemic.
- - The research suggests that TGWT+ individuals actively engage with health services in meaningful ways, and emphasizes the need for more nuanced studies to enhance prevention and care strategies during health crises.
Objective: To analyze the impact of intersecting systems of oppression on the continuum of PrEP care among adolescent gays, bisexuals, and other men who have sex with men (aGBMSM), and to examine how health professionals (HP) identify and address these challenges to provide sexual health care and HIV prevention.
Methods: This qualitative exploratory study was part of a cohort research project involving aGBMSM, travesties, and transgender women (aTrTW) using PrEP. Data analyzed consisted of 16 interviews with aGBMSM and eight with health professionals (HPs) in São Paulo study site.