Publications by authors named "P T Kovacevic"
Background: Pulse pressure variation (PPV) is limited in low tidal volume mechanical ventilation. We conducted this systematic review and meta-analysis to evaluate whether passive leg raising (PLR)-induced changes in PPV can reliably predict preload/fluid responsiveness in mechanically ventilated patients with low tidal volume in the intensive care unit.
Methods: PubMed, Embase, and Cochrane databases were screened for diagnostic research relevant to the predictability of PPV change after PLR in low-tidal volume mechanically ventilated patients.
Long-term use of topical prostaglandins might initiate chronic conjunctival inflammation, leading to poor outcomes of glaucoma surgery. The aim of this study was to evaluate the immunoexpression pattern of HSP70, CTGF, SNAIL, aSMA, cMYB, and HIFa in the conjunctiva, episclera, and deep sclera in patients with glaucoma undergoing deep sclerectomy in order to establish an association between staining intensities and prostaglandin F2 (PGF2) treatment. Double immunofluorescence (HSP70, CTGF, SNAIL, aSMA, cMYB, and HIFa) was performed on conjunctiva, episclera, and deep sclera samples, which were obtained from 23 patients treated with PGF2 and 8 patients without PGF2 treatment.
View Article and Find Full Text PDFOxidative stress represents an imbalance between oxidants and antioxidants, with a predominance of oxidants leading to cellular and tissue damage. Given the limited number of studies showing the predictive value of oxidative stress factors regarding sepsis type, the objectives of this study emerged as follows: to determine whether pro-oxidant and antioxidant values could predictively differentiate between Gram-positive (GP) and Gram-negative (GN) sepsis. Additionally, the study sought to assess whether bacterial type impacts treatment outcomes in sepsis patients.
View Article and Find Full Text PDFArticle Synopsis
- A 38-year-old male was admitted during COVID-19 with symptoms like fever and cough, but initial tests showed no lung issues and elevated procalcitonin levels.
- After 7 days of antibiotics with no improvement in PCT, further testing revealed medullary thyroid microcarcinoma.
- The patient underwent surgery to remove the thyroid and lymph nodes, but chose not to pursue additional treatment; follow-up scans showed no new growths over two years.
Article Synopsis
- - The COVID-19 pandemic highlighted the deficiencies in intensive care medicine in low-resource settings (LRS), prompting a need for expert recommendations on establishing medical critical care.
- - An international conference in December 2023, organized by the National Association of Intensivists from Bosnia and Herzegovina, involved 48 clinicians from 20 countries who used a modified Delphi methodology to reach consensus on key statements regarding organizational structure, staffing, and education for critical care units in LRS.
- - The conference concluded with 13 out of 16 statements achieving consensus, emphasizing the importance of specialized training, multispecialty units, healthcare authority recognition, and the role of technology in improving critical care in LRS.