Publications by authors named "P T Helen"
Predisposing factors underlying familial aggregation of non-syndromic gliomas are still to be uncovered. Whole-exome sequencing was performed in four Finnish families with brain tumors to identify rare predisposing variants. A total of 417 detected exome variants and 102 previously reported glioma-related variants were further genotyped in 19 Finnish families with brain tumors using targeted sequencing.
View Article and Find Full Text PDFAtypical teratoid/rhabdoid tumors (AT/RTs) are pediatric brain tumors known for their aggressiveness and aberrant but still unresolved epigenetic regulation. To better understand their malignancy, we investigated how AT/RT-specific DNA hypermethylation was associated with gene expression and altered transcription factor binding and how it is linked to upstream regulation. Medulloblastomas, choroid plexus tumors, pluripotent stem cells, and fetal brain were used as references.
View Article and Find Full Text PDFPurpose: The purpose of this study is to determine if 2.5-year-olds with language delay would learn verbs () when presented with varying syntactic structure ("The woman is spilling the milk"/"The milk is spilling"; = patient or theme) in a therapeutic context. Children with language delay have proportionally small inventories of verbs, which limits expressive language development.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on the progression of low-grade diffuse astrocytomas into grade 4 tumors and its impact on patient outcomes, highlighting the need for better understanding to enhance patient care.
- Researchers analyzed genetic data from a cohort of patients with IDH-mutant astrocytomas, revealing significant alterations like increased chromosomal rearrangements and inactivation of key genes related to cell cycle regulation after treatment.
- Results indicate that combined postoperative radiation and chemotherapy, especially temozolomide, may lead to improved survival outcomes, particularly in patients with grade 3 tumors, suggesting a need for more effective treatment strategies.
Background: The purpose of our study was to analyze the impact of time interval from referral to surgery and from surgery to adjuvant treatment on survival of adult isocitrate dehydrogenase-wild-type (IDH-wt) glioblastomas.
Methods: Data on 392 IDH-wt glioblastomas diagnosed at the Tampere University Hospital in 2004-2016 were obtained from the electronic patient record system. Piecewise Cox regression was used to calculate hazard ratios for different time intervals between referral and surgery, as well as between surgery and adjuvant treatments.