Publications by authors named "P T Greenland"
Importance: Short sleep duration during pregnancy and the perimenopausal period has been associated with adverse cardiometabolic outcomes. However, it remains unclear how sleep duration changes after delivery and whether such changes are associated with the cardiometabolic health of birthing people.
Objective: To investigate whether persistently short sleep during pregnancy and after delivery is associated with incident hypertension and metabolic syndrome.
Article Synopsis
- A study examined how inflammatory diets impact cardiovascular health, particularly in relation to adverse pregnancy outcomes (APOs) like preterm birth and gestational diabetes.
- Data from over 3,200 pregnant individuals showed that higher inflammatory diet scores correlated with increased body mass index, waist circumference, blood pressure, triglycerides, and insulin levels, along with lower good cholesterol levels.
- The study found that the negative impact of inflammatory diets on cardiometabolic health was more pronounced in individuals who experienced APOs during pregnancy.
Objective: This study aimed to investigate serum metabolomic biomarkers associated with incident type 2 diabetes mellitus (T2DM) and evaluate their performance in improving T2DM risk prediction.
Methods: Untargeted proton nuclear magnetic resonance (1H NMR) spectroscopy-based metabolomics analyses were conducted in the Multi-Ethnic Study of Atherosclerosis (MESA; n=3460; discovery cohort) and Rotterdam Study (RS; n=1556; replication cohort). Multivariable cause-specific hazards models were used to analyze the associations between 23,571 serum metabolomic spectral variables and incident T2DM.
A common missense variant in among African American individuals (rs5491; pK56M) has been associated with risk of heart failure with preserved ejection fraction (HFpEF), but the pathways that lead to HFpEF among those with this variant are not clear. In this analysis of 92 circulating proteins and their associated networks, we identified 7 circulating inflammatory proteins associated with rs5491 among >600 African American individuals. Using weighted coexpression network analysis, 3 protein networks were identified, one of which was associated with rs5491.
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