Publications by authors named "P T Coates"
Article Synopsis
- - TP73, part of the TP53 gene family, produces different protein variants (TAp73 and ΔTAp73) with opposing functions through various genetic mechanisms.
- - Newly developed antibodies for these p73 variants reveal that TAp73 is present in multiciliated epithelial cells, while ΔTAp73 marks non-proliferative basal cells in squamous epithelium.
- - In cervical squamous cell carcinomas, p73α is commonly expressed and linked to lower tumor grades, whereas TAp73 appears less frequently and does not show significant associations with cancer characteristics.
Stress responses play a vital role in cellular survival against environmental challenges, often exploited by cancer cells to proliferate, counteract genomic instability, and resist therapeutic stress. Heat shock factor protein 1 (HSF1), a central transcription factor in stress response pathways, exhibits markedly elevated activity in cancer. Despite extensive research into the transcriptional role of HSF1, the mechanisms underlying its activation remain elusive.
View Article and Find Full Text PDFThe p53 family of proteins evolved from a common ancestor into three separate genes encoding proteins that act as transcription factors with distinct cellular roles. Isoforms of each member that lack specific regions or domains are suggested to result from alternative transcription start sites, alternative splicing or alternative translation initiation, and have the potential to exponentially increase the functional repertoire of each gene. However, evidence supporting the presence of individual protein variants at functional levels is often limited and is inferred by mRNA detection using highly sensitive amplification techniques.
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- * The study examines how devulcanization alters the types and amounts of sulfur cross-links in rubber, which affects its ability to be re-vulcanized.
- * Two different curing methods were tested to see if modifying the sulfur and accelerator ratio could change the sulfur composition of revulcanized rubber, but both methods still led to the majority of cross-links being polysulfidic.
Article Synopsis
- Management decisions in wildlife conservation should consider both habitat selection and demographic performance, as habitat selection alone may not reflect true species viability.
- This study focuses on the greater sage-grouse to illustrate how mapping habitat selection against survival rates can reveal important mismatches and trade-offs throughout different reproductive life stages.
- By integrating demographic measures into habitat management, conservation efforts can be more effectively tailored to enhance species survival and resource allocation, particularly during critical life stages.