Publications by authors named "P T A M Lips"
Context: Low vitamin D status is common and is associated with various common medical conditions.
Objective: To support the development of the Endocrine Society's Clinical Practice Guideline on Vitamin D for the Prevention of Disease.
Methods: We searched multiple databases for studies that addressed 14 clinical questions prioritized by the guideline panel.
Background: Numerous studies demonstrate associations between serum concentrations of 25-hydroxyvitamin D (25[OH]D) and a variety of common disorders, including musculoskeletal, metabolic, cardiovascular, malignant, autoimmune, and infectious diseases. Although a causal link between serum 25(OH)D concentrations and many disorders has not been clearly established, these associations have led to widespread supplementation with vitamin D and increased laboratory testing for 25(OH)D in the general population. The benefit-risk ratio of this increase in vitamin D use is not clear, and the optimal vitamin D intake and the role of testing for 25(OH)D for disease prevention remain uncertain.
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- The study investigates how peak expiratory flow rate (PEFR), an indicator of health outcomes, changes with age among older adults in a 13-year follow-up.
- It identifies three declining PEFR trajectories in older men (high, intermediate, low) and two in women (high, low), with different prevalence rates and notable health characteristics linked to each trajectory.
- The findings suggest that a single PEFR measurement can predict an older adult's likely health trajectory, as differences in PEFR trajectories are mainly based on initial levels rather than the rate of decline.
Background: Two previous meta-analyses showed smaller differences between vitamin D3 and vitamin D2 in raising serum 25-hydroxyvitamin D [25(OH)D] and a consistently high heterogeneity when only including daily dosing studies.
Objective: This study aimed to compare more frequently dosed vitamin D2 and vitamin D3 in improving total 25(OH)D and determine the concomitant effect of response modifiers on heterogeneity, and secondly, to compare the vitamin D2-associated change in 25(OH)D2 with the vitamin D3-associated change in 25(OH)D3.
Methods: PubMed, EMBASE, Cochrane, and the Web of Science Core collection were searched for randomized controlled trials of vitamin D2 compared with vitamin D3, daily or once/twice weekly dosed.
Methodological aspects of axial loading in rodents: a systematic review.
J Musculoskelet Neuronal Interact
June 2023
Axial loading in rodents provides a controlled setting for mechanical loading, because load and subsequent strain, frequency, number of cycles and rest insertion between cycles, are precisely defined. These methodological aspects as well as factors, such as ovariectomy, aging, and disuse may affect the outcome of the loading test, including bone mass, structure, and bone mineral density. This review aims to overview methodological aspects and modifying factors in axial loading on bone outcomes.
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