Effects of prolonged oxytetracycline supplementation on freshwater stinging catfish (): a multi-biomarker approach.

Background: Aquaculture systems that sporadically depend on antibiotics can contribute to the development of adverse effects on the fish, microbial flora and the environment. This study sought to investigate the impacts of extended oxytetracycline supplementation on the freshwater stinging catfish through a multi-biomarker approach.

Methods: A total of 300 (20 ± 0.

Multimodal antibacterial potency of newly designed and synthesized Schiff's/Mannich based coumarin derivatives: potential inhibitors of bacterial DNA gyrase and biofilm production.

The briskened urge to develop potential antibacterial candidates against multidrug-resistant pathogens has motivated the present research study. Herein, newly synthesized coumarin derivatives with azomethine and amino-methylated as the functional groups have been focused on their antibacterial efficacy. The study proposed two distinct series: 3-acetyl substituted coumarin derivatives, followed by the Schiff base approach (5a-5i), and formaldehyde-secondary cyclic amine-based derivatives (7a-7g), using the Mannich base approach, further the compounds have been confirmed through various spectral studies.

Navigating the sea level rise: Exploring the interplay of climate change, sea level rise, and coastal communities in india.

This research article investigates the intricate interplay between climate change, global sea level rise (SLR), and the impacts of sea level rise on the coastal regions of India. Through an interdisciplinary approach, this paper provides an overview of the global consequences of SLR on coastal communities, exploring economic, social, and environmental impacts on agriculture, communities, and coastal areas. The study examines the displacement of communities and its impact on food security, infrastructure, tourism, and ecological loss based on a comprehensive literature review.

Dysregulated nicotinamide adenine dinucleotide metabolome in patients hospitalized with COVID-19.

Nicotinamide adenine dinucleotide (NAD) depletion has been postulated as a contributor to the severity of COVID-19; however, no study has prospectively characterized NAD and its metabolites in relation to disease severity in patients with COVID-19. We measured NAD and its metabolites in 56 hospitalized patients with COVID-19 and in two control groups without COVID-19: (1) 31 age- and sex-matched adults with comorbidities, and (2) 30 adults without comorbidities. Blood NAD concentrations in COVID-19 group were only slightly lower than in the control groups (p < 0.