Publications by authors named "P Sultanik"
Background & Aims: Data on the association between proton pump inhibitor (PPI) use and hepatic encephalopathy (HE) are conflicting, and data from multicentre studies are scarce. The aim of this study was to dissect the potential association between PPI use and minimal (MHE) and overt HE (OHE).
Methods: Data from patients with cirrhosis recruited at seven centres across Europe and the US were analysed.
Background And Aims: The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD)-related cirrhosis has been increasing these last decades. There are no data regarding the prevalence of MASLD-related cirrhosis in intensive care unit (ICU).
Methods: Prospective single-centre study in a cohort of patients hospitalized in the ICU of Hepatology La Pitié-Salpêtrière Hospital between January 2019 and September 2021.
Background/aims: Although it is well admitted that cirrhotic patients display various causes of neurocognitive impairment (NI) hampering the diagnosis of covert hepatic encephalopathy (CHE), those are almost never investigated per se. The aims of this study were, in cirrhotic patients displaying cognitive complaints explored by a complete multimodal work-up, to assess: (1) the prevalence of CHE and/or that of other causes of NI and (2) their outcomes, according to the cause of NI.
Methods: Prospective cohort of cirrhotic patients referred in a dedicated clinic because of cognitive complaints.
Article Synopsis
- Minimal hepatic encephalopathy (MHE) is linked to a greater risk of overt hepatic encephalopathy (OHE) as measured by the portosystemic hepatic encephalopathy score (PHES).
- A multicenter study followed patients with MHE to see if worse PHES results led to a progressively higher risk of developing OHE.
- Findings showed that while abnormal PHES indicates a higher chance of OHE, there isn't a stepwise increase in risk as PHES scores worsen beyond a certain threshold.