Publications by authors named "P Steptoe"
Purpose: To develop Choroidalyzer, an open-source, end-to-end pipeline for segmenting the choroid region, vessels, and fovea, and deriving choroidal thickness, area, and vascular index.
Methods: We used 5600 OCT B-scans (233 subjects, six systemic disease cohorts, three device types, two manufacturers). To generate region and vessel ground-truths, we used state-of-the-art automatic methods following manual correction of inaccurate segmentations, with foveal positions manually annotated.
Purpose: To assess the efficacy of treatment on acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and relentless placoid chorioretinopathy (RPC).
Methods: Cases were identified from three UK uveitis centers. Retrospective analysis of visual acuity recovery; OCT structural outcomes; and retinal lesion quantification in observed and treated cases of APMPPE/RPC.
Article Synopsis
- - The study compares the retinal lesions in patients with punctate inner choroidopathy (PIC) and Ebola virus disease (EVD) retinopathy, noting similarities in their appearance on optical coherence tomography despite differences in color imaging.
- - Both conditions displayed a specific pattern characterized by focal photoreceptor loss and a V-shaped collapse of retinal layers, which also resembles lesions seen in a mouse model of herpes simplex virus (HSV) retinopathy.
- - The findings suggest a potential shared pathophysiological mechanism behind these retinal conditions, opening up avenues for further research into PIC and its connections to viral retinal diseases.
Article Synopsis
- The study investigates the mechanisms behind acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and relentless placoid chorioretinitis (RPC) by comparing them to a viral retinal infection model in animals.
- Evidence suggests a possible viral cause for APMPPE based on rising viral titers and disruption in retinal axoplasmic flow leading to clinical symptoms.
- The findings indicate that neurotrophic viral infections may better explain the observed imaging characteristics of APMPPE and RPC compared to previous theories focused on blood flow issues.