Publications by authors named "P Steindl-Munda"
Background: Portal hypertension (PH) does not resolve in a considerable proportion of patients who achieved HCV-cure.
Aims: To investigate (i)whether HCV-cure impacts cytokines that orchestrate angiogenesis (i.e.
Genetic variants including and have been shown to influence progression to advanced chronic liver disease (ACLD) in patients with chronic hepatitis C (CHC). We aimed to investigate their impact on disease regression (i.e.
View Article and Find Full Text PDFBackground And Aims: Risk stratification after cure from hepatitis C virus (HCV) infection remains a clinical challenge. We investigated the predictive value of noninvasive surrogates of portal hypertension (liver stiffness measurement [LSM] by vibration-controlled transient elastography and von Willebrand factor/platelet count ratio [VITRO]) for development of hepatic decompensation and hepatocellular carcinoma in patients with pretreatment advanced chronic liver disease (ACLD) who achieved HCV cure.
Approach And Results: A total of 276 patients with pretreatment ACLD and information on pretreatment and posttreatment follow-up (FU)-LSM and FU-VITRO were followed for a median of 36.
Background And Aims: Sustained virologic response (SVR) to interferon (IFN)-free therapies ameliorates portal hypertension (PH); however, it remains unclear whether a decrease in hepatic venous pressure gradient (HVPG) after cure of hepatitis C translates into a clinical benefit. We assessed the impact of pretreatment HVPG, changes in HVPG, and posttreatment HVPG on the development of hepatic decompensation in patients with PH who achieved SVR to IFN-free therapy. Moreover, we evaluated transient elastography (TE) and von Willebrand factor to platelet count ratio (VITRO) as noninvasive methods for monitoring the evolution of PH.
View Article and Find Full Text PDFArticle Synopsis
- Wilson disease (WD) is an inherited disorder affecting how the body processes copper, primarily causing liver disease and neuropsychiatric symptoms; this study examined clinical presentations among 1,357 WD patients.* -
- The patients were classified based on their symptoms, with 711 showing liver disease and 461 showing neurological disease; 52.7% had a liver biopsy at diagnosis and multiple genetic mutations were identified, with the most common being H1069Q.* -
- No direct link was found between specific mutations and clinical symptoms, though gender differences emerged, with hepatic issues more common in females and neurological issues in males; a significant number of patients, especially adults, already showed signs of cirrhosis at diagnosis