Publications by authors named "P Spill"
Background: Current forms of peanut oral immunotherapy (OIT) are associated with side effects, and there is a lack of evidence addressing how to mitigate them.
Objective: To determine whether premedication with desloratadine and ranitidine results in fewer side effects during peanut OIT/desensitization.
Methods: A total of 43 patients with peanut allergy (mean age, 7.
Background: There are a lack of disease-modifying treatments for peanut allergy, which is lifelong in most instances. Oral immunotherapy has remained at the forefront of prospective treatments, though its efficacy is consistently undermined by the risk of adverse reactions and meager sustained effects.
Aim: This review discusses the current state of oral immunotherapy, its strengths and limitations, and the future of therapeutics for the treatment of peanut allergy.
Article Synopsis
- IgE production against harmless foods can lead to dangerous allergic reactions like anaphylaxis, with IgG memory B cells playing a key role in maintaining IgE immunity.
- The research aimed to uncover what is necessary for the IgE recall response specifically in peanut allergies, utilizing human PBMC cultures and a mouse allergy model.
- Results showed that blocking IL-4/IL-13 signaling stopped IgE production and altered immune responses, while anti-IL-4Rα treatment in mice provided lasting protection against allergic reactions and anaphylaxis.