Publications by authors named "P Spassova"

Problem: We evaluated implantation-associated quantitative changes in endometrial and peripheral natural killer (NK)-cell populations of pigs.

Method Of Study: Natural killer cell populations were investigated in 10, 15, 20, 30 and 40 days pregnant and non-pregnant (NP) sows by flow cytometry, immunohistochemistry and morphometry.

Results: The number of endometrial CD16(+) NK cells significantly declined at attachment phase of implantation and remained relatively low over the course of implantation.

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Article Synopsis
  • The study focused on how implantation affects T lymphocyte changes in the blood and endometrium of pregnant sows.
  • Researchers used flow cytometry and immunohistochemistry to analyze T-cell subsets in sows at various stages of pregnancy.
  • Results showed that T cells peaked during implantation, particularly Tc and Th cells, while the number of gamma-delta T lymphocytes was minor and unaffected by implantation.
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In this study we present for the first time HLA class I allele and haplotype frequencies at DNA level in the Bulgarian population. HLA class I profile of Bulgarians has been compared to other European and Mediterranean populations of common historical background in order to clarify more precisely the origin of our population. Genetic distances, phylogenetic trees and correspondence analyses show that the Bulgarian population is more closely related to the Italian, the Mediterranean, the Armenian and the Romanian population than to the other East and West European population.

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Our unit was established in 1972 as Laboratory of Clinical Immunology in the Department of Nephrology, Medical Academy, Sofia Since 1985 it was expanded in Division of Clinical and Transplantation Immunology. Transplantation activity includes: HLA typing (serology and DNA) of all kind of recipients and donors, alloantibody screening and crossmatching (basic microlymphocytotoxicity, DTT and flowcytometry tests). Immunologic evaluation of patients prior to and after transplantation is also performed for individualization of immunosuppressive therapy and discrimination between rejection, CMV infection and cyclosporine toxicity.

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