Publications by authors named "P Spagnolo"
Background: There has been significant progress in understanding neurosarcoidosis (NS) as a distinct disorder, which encompasses a heterogeneous group of clinical and radiological alterations which can affect patients with systemic sarcoidosis or manifest isolated.
Rationale And Aim Of The Study: The healthcare challenges posed by NS and sarcoidosis in general extend beyond their physical symptoms and can include a variety of psychosocial factors, therefore the recognition of main neuropsychiatric symptoms can be useful to approach patients with NS. Methods: For this purpose, databases such as Pubmed, Medline and Pubmed Central (PMC) have been searched.
Background: Diabetic ketoacidosis (DKA) is a serious complication of type 1 diabetes (T1D), arising from relative insulin deficiency and leading to hyperglycemia, ketonemia, and metabolic acidosis. Early detection and treatment are essential to prevent severe outcomes. This pediatric case-control study utilized plasma metabolomics to explore metabolic alterations associated with DKA and to identify predictive metabolite patterns.
View Article and Find Full Text PDFWhat rationale for treatment of occupational interstitial lung diseases with the drugs approved for idiopathic pulmonary fibrosis?
Curr Opin Allergy Clin Immunol
December 2024
Purpose Of Review: To critically discuss the rationale for the use of drugs approved for idiopathic pulmonary fibrosis (IPF) to treat occupational interstitial lung diseases (OILDs).
Recent Findings: Although IPF and OILDs share several clinical, radiological and probably pathogenetic features, currently, OILDs do not have a standard of care. In recent years, our knowledge and understanding of ILDs has improved substantially.
Article Synopsis
- The study focuses on detecting multijet signatures from proton-proton collisions at a high energy of 13 TeV, analyzing a dataset totaling 128 fb^{-1}.
- A special data scouting method is utilized to pick out events with low combined momentum in jets.
- This research is pioneering in its investigation of electroweak particle production in R-parity violating supersymmetric models, particularly examining hadronically decaying mass-degenerate higgsinos, and it broadens the limits on the existence of R-parity violating top squarks and gluinos.
Article Synopsis
- Surgical treatment for lung cancer in patients with idiopathic pulmonary fibrosis carries risks of severe complications, particularly acute exacerbation during the recovery period.
- This study evaluated 55 patients who underwent lung resection, comparing those on anti-fibrotic drugs with those who weren't; results showed a significantly lower incidence of acute exacerbation in the treated group (3.4% vs. 23.1%).
- While the use of anti-fibrotic therapy was associated with reduced acute exacerbation rates, it did not lead to a significant difference in 30- and 90-day mortality rates between the two groups.