Publications by authors named "P Sondo"
Article Synopsis
- Asymptomatic carriers of Plasmodium falciparum play a crucial role in malaria transmission, prompting a study to assess malaria infection levels among household members of children receiving seasonal malaria chemoprevention (SMC).
- The study, which involved 745 participants and used various diagnostic tests, found that 26.58% of participants carried asexual forms of the parasite, with the highest prevalence (35.76%) among children aged 5 to 15 years.
- The ultrasensitive rapid diagnostic test (usRDT) showed greater sensitivity for detecting malaria compared to the standard rapid diagnostic test (rRDT), suggesting that usRDT is more effective for community-based screening and treatment strategies.
Seasonal Malaria Chemoprevention consisting of monthly administration of amodiaquine/sulfadoxine-pyrimethamine to children aged 3-59 months during the transmission season could promote SP-resistance. Mutations in dihydrofolate reductase (Pfdhfr) and dihydropteroate synthase (Pfdhps) genes were assessed before and after SMC adoption in Burkina Faso. A total of 769 dried blood spots were selected from studies conducted in Nanoro, Burkina Faso, between 2010 and 2020.
View Article and Find Full Text PDFBackground: Seasonal malaria chemoprevention (SMC) is an effective malaria preventive intervention in sub-Sahara Africa. However, as with any other drug-based intervention, the large-scale deployment of this strategy could lead to Amodiaquine plus Sulfadoxine-Pyrimethamine (AQSP) drug pressure on the circulating parasites population with selection for specific alleles that could compromise the impact of the intervention in the near future. This study aimed to assess the distribution of the Pfmdr1 mutation involved in resistance to AQ before and after the annual campaign of SMC in the health district of Nanoro.
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- In rural Burkina Faso, a study was conducted to assess the impact of combining Seasonal Malaria Chemoprevention (SMC) with nutrient supplementation among undernourished children under five years old, due to high levels of both malaria and malnutrition in the area.
- The study involved 1059 children divided into three groups, each receiving different combinations of SMC and nutritional interventions, followed over a year to monitor malaria incidence and overall health through regular check-ups.
- Results showed that adding lipid-based nutrient supplements (PlumpyDoz) significantly reduced both uncomplicated malaria (by 23%) and severe malaria (by 52%) compared to the control group, also lowering general illness rates by 24%, while no effect was found on
Seasonal Malaria chemoprevention (SMC) is one of the large-scale life-saving malaria interventions initially recommended for the Sahel subregion, including Burkina Faso and recently extended to other parts of Africa. Initially, SMC was restricted to children 3 to 59 months old, but an extension to older children in some locations was recently recommended. Further characterization of SMC population profile beyond age criterion is necessary for understanding factors that could negatively impact the effectiveness of the intervention and to define complementary measures that could enhance its impact.
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