Publications by authors named "P Solbach"

Article Synopsis
  • Clostridioides difficile (C. difficile) is a major cause of healthcare-related diarrhea, with issues like antibiotic resistance and high relapse rates complicating treatment.
  • *Faecal microbiota transplantation is a potential therapy but understanding the key factors for successful colonization resistance is necessary for its broader application.
  • *Experts highlighted the need for a Controlled Human Infection Model (CHIM) to safely study mild to moderate C. difficile infections, which could lead to new treatments and better insights into how the infection works.*
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Objectives: The objective of this study is to examine the comparative effectiveness of vancomycin and metronidazole in a confirmatory analysis of event-free survival (EFS) after initial infection in patients with Clostridioides difficile from a German multicentre cohort study.

Methods: The IBIS multicentre cohort enrolled patients with an index episode of C. difficile infection between August 2017 and September 2020.

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Background: Accurate biomarkers for disease activity and progression in patients with inflammatory bowel disease (IBD) are a prerequisite for individual disease characterization and personalized therapy. We show that metabolic profiling of serum from IBD patients is a promising approach to establish biomarkers. The aim of this work was to characterize metabolomic and lipidomic serum profiles of IBD patients in order to identify metabolic fingerprints unique to the disease.

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Article Synopsis
  • Bacterial cholangitis often occurs in liver transplant patients with biliary issues, requiring antibiotics and endoscopic procedures, but standard microbiological cultivation (SMC) has limitations in identifying all bacterial species.
  • A study involving 242 bile samples utilized next generation sequencing (NGS) to assess its effectiveness compared to SMC, revealing that NGS detected significantly more bacterial genera.
  • The findings suggest that NGS is a more sensitive diagnostic tool than SMC, indicating that using both methods together can enhance the identification of bacteria in bile and lead to better-targeted antibiotic therapies.
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Introduction: Bile has long been considered sterile. Recent studies show that bacteria can frequently be detected in bile and certain bacterial species are associated with bile duct-associated liver disease.

Objectives: To detect bacterial species and antibiotic resistance in bile in bile duct-associated liver disease.

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