Antimicrobial and antiparasitic potential of lupeol: antifungal effect on the species complex and nematicidal activity against .

There is growing concern about infections caused by non- species, including species of the complex - which have seen a considerable increase in cases during the COVID-19 pandemic - in addition to concern about nematode resistance to currently used anthelmintics. Lupeol is a triterpenoid phytosterol that has a wide range of biological activities, although its antifungal and antiparasitic potential is still poorly explored. Additionally, its effect on the biofilm of the species complex has not yet been studied.

Advanced amphotericin-B gel formulation: An efficient approach to combat cutaneous leishmaniasis.

Several drug release studies are continuously carried out to minimize pharmacological limitations, such as insolubility in water and gastrointestinal irritability. This study focused on the development of gels for the administration of amphotericin-B (AmB) for the treatment of cutaneous leishmaniasis. Two gels were prepared from copolymers (polyglycerol and ε-caprolactone) incorporated with AmB.

Use of medications in women with triple-negative breast cancer between 2018 and 2019 in a Brazilian public hospital: a retrospective study.

Objective: To describe the profile of medication use in women with triple-negative breast cancer treated between 2018 and 2019 in a Brazilian public hospital.

Methods: Descriptive and retrospective study, with data obtained from the Hospital Cancer Registry and physical and electronic medical records from a public hospital that is a reference in cancer treatment, in Rio de Janeiro. Descriptive analyses and analyses of time to treatment failure and overall survival were performed using the Kaplan Meier method.

Endothelial TRPV4-Cx43 signalling complex regulates vasomotor tone in resistance arteries.

S-nitrosylation of Cx43 gap junction channels critically regulates communication between smooth muscle cells and endothelial cells. This post-translational modification also induces the opening of undocked Cx43 hemichannels. However, its specific impact on vasomotor regulation remains unclear.

Awareness for the risk of adverse outcomes of female patients after ST-segment elevation acute coronary syndrome.

Introduction: Women increased risk of early mortality following ST-segment elevation myocardial infarction (STEMI) has been attributed to older age, more comorbidities, and less primary revascularization (PCI). Data on long-term outcomes is conflicting, and younger patients' specific evidence is limited.

Purpose: Compare gender outcomes following STEMI within a cohort of younger (≤55 years) and older (>55 years) individuals.