Publications by authors named "P Slickers"
Article Synopsis
- * Researchers analyzed whole-genome sequences from 340 bacterial isolates across 14 countries to understand the clone's evolutionary history and how it transmits, particularly through travel and family connections.
- * The findings emphasize the role of a specific plasmid in developing multidrug resistance and highlight the necessity of whole-genome sequencing for tracking resistant pathogens, aiding in global surveillance efforts.
Article Synopsis
- Fusidic acid is a steroid antibiotic used topically for skin infections caused by Staphylococcus aureus, particularly in the face of increasing methicillin-resistant strains (MRSA) that possess specific resistance genes.
- The study explored MRSA isolates from the Arabian Gulf, revealing previously unreported variants of SCCmec elements with the fusC resistance gene, suggesting complex genetic relationships among strains from different countries.
- The findings indicate that MRSA strains with these resistance genes may have a competitive advantage in healthcare and community environments, highlighting the need to reconsider the use of topical antibiotics and restrict their sale without prescriptions.
Objectives: We assessed the efficacy and safety of an oral antimicrobial regimen for short- and long-term intestinal eradication of ESBL-producing Escherichia coli and Klebsiella pneumoniae (ESBL-EC/KP) in immunocompromised patients.
Methods: We performed a randomized (2:1), double-blind multicentre Phase II study in four haematology-oncology departments. Patients colonized with ESBL-EC/KP received a 7 day antimicrobial regimen of oral colistin (2 × 106 IU 4×/day), gentamicin (80 mg 4×/day) and fosfomycin (three administrations of 3 g every 72 h), or placebo.
In recent years an increasing number of methicillin-resistant S. pseudintermedius (MRSP) has been observed in both, healthy and clinically infected dogs. The aim of the study was the characterisation of MRSP isolates from clinical routine diagnostics of a German laboratory in order to assess the abundancy of resistance genes and SCCmec elements.
View Article and Find Full Text PDFThe presence of the methicillin resistance gene mecC in coagulase-negative Staphylococcus spp. (CoNS) is scarce. The aim of this study was to characterize mecC-positive CoNS isolated from various wild and domestic animals.
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