Dying of pestilence: Stature and mortality from the Black Death in 14th-century Kyrgyzstan.

Objectives: Bioarchaeological studies have provided important information about mortality patterns during the second pandemic of plague, including the Black Death, but most to date have focused on European contexts. This study represents a spatial contribution to plague bioarchaeology, focusing on Central Asia, the origin of the second pandemic. We examine the relationship between stature and plague mortality during an outbreak of plague at Kara-Djigach in northern Kyrgyzstan in 1338-1339, the earliest archaeological site known to contain victims of the Black Death in Eurasia.

and Plague: some knowns and unknowns.

Since its first identification in 1894 during the third pandemic in Hong Kong, there has been significant progress of understanding the lifestyle of , the pathogen that is responsible for plague. Although we now have some understanding of the pathogen's physiology, genetics, genomics, evolution, gene regulation, pathogenesis and immunity, there are many unknown aspects of the pathogen and its disease development. Here, we focus on some of the knowns and unknowns relating to and plague.

14th century Yersinia pestis genomes support emergence of pestis secunda within Europe.

Pestis secunda (1356-1366 CE) is the first of a series of plague outbreaks in Europe that followed the Black Death (1346-1353 CE). Collectively this period is called the Second Pandemic. From a genomic perspective, the majority of post-Black Death strains of Yersinia pestis thus far identified in Europe display diversity accumulated over a period of centuries that form a terminal sub-branch of the Y.