Publications by authors named "P Skrzypczyk"
Studies in adults have demonstrated the essential role of microRNAs in developing hypertension and their effect on hypertension sequelae. In this preliminary study, we aimed to investigate the expression of five miRNA particles, miRNA-21, miRNA-27a, miRNA-27b, miRNA-133a, and miRNA-145, in school-aged children with primary hypertension and to examine their correlations with blood pressure and arterial and heart properties. In 22 hypertensive children (15.
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- Renal artery stenosis (RAS) and mid-aortic syndrome (MAS) are important but often overlooked causes of high blood pressure in children, with RAS involving the narrowing of renal arteries and MAS affecting the abdominal aorta and associated vessels.
- These conditions can arise from genetic issues and other factors like fibromuscular dysplasia and Takayasu arteritis, making their symptoms complicated and hard to diagnose despite improved imaging techniques.
- Treatment varies from medications that only partially control blood pressure to more invasive options like angioplasty and surgery, and the article emphasizes the need for a multidisciplinary approach and early detection to improve treatment outcomes for affected children.
Background: One defining feature of various aggressive cancers, including glioblastoma multiforme (GBM), is glycolysis upregulation, making its inhibition a promising therapeutic approach. One promising compound is 2-deoxy-d-glucose (2-DG), a d-glucose analog with high clinical potential due to its ability to inhibit glycolysis. Upon uptake, 2-DG is phosphorylated by hexokinase to 2-DG-6-phosphate, which inhibits hexokinase and downstream glycolytic enzymes.
View Article and Find Full Text PDFInformation is instrumental in our understanding of thermodynamics. Their interplay has been studied through completely degenerate Hamiltonians whereby the informational contributions to thermodynamic transformations can be isolated. In this setting, all states other than the maximally mixed state are considered to be in informational nonequilibrium.
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- mRNA-based drugs are rapidly advancing, particularly as viral vaccines, with potential uses in various diseases due to their easy and adaptable production process.
- The structure of mRNA components, especially modifications at the 5' cap, significantly influences its effectiveness and longevity in medical applications.
- This study focuses on synthesizing modified cap analogues and testing these compounds for their ability to act as translation inhibitors and improve mRNA preparation.