Plasma alpha-lipoprotein pattern and LCAT activity in acute viral hepatitis in children.

The alpha-lipoprotein (a-Lp) electrophoretic pattern on agarose gel was studied serially in 65 children with acute viral hepatitis. In seven cases the high-density lipoprotein fractions (HDL) were also separated by ultracentrifugation and studied in relation to lecithin: cholesterol acyltransferase activity (LCAT) during the acute phase and recovery. The a-Lp band was initially absent on electrophoresis in 36 cases and never appeared in 3 of the children who died.

Abnormal lipoproteins in multiple myelomatosis.

In a study of the lipoprotein pattern in multiple myelomatosis electrophoresis on agarose gel showed abnormal lipoproteins, named paralipoproteins (p-Lp), in 24 out of 30 normolipidaemic patients. These paralipoproteins were grouped according to their mobility into one or another of the following types: (1) p-Lp1 with a mobility identical with that of gamma-globulin, (2) p-Lp2 with a mobility between that of beta- and gamma-globulin, (3) p-Lp3 with a mobility identical with that of beta-globulin. On ultracentrifugation the abnormal lipoproteins were found to have a density above 1-063 g/ml.