Publications by authors named "P Skalicky"
Currently, no international consensus includes surgery as part of the standard of metastatic pancreatic ductal adenocarcinoma care. There is weak evidence to support the general introduction of surgical resection in the metastatic pancreatic ductal adenocarcinoma treatment. However, in the rare cases of oligometastatic spread there is increasing evidence that surgical intervention can lead to favourable outcomes.
View Article and Find Full Text PDFVolumes and velocities: Meta-analysis of PC-MRI studies in normal pressure hydrocephalus.
Acta Neurochir (Wien)
November 2024
Unlabelled: PURPOSE : Phase contrast magnetic resonance imaging (PC-MRI) represents an opportunity to non-invasively investigate cerebral spinal fluid (CSF) flow in patients with idiopathic normal pressure hydrocephalus (iNPH). Studies in recent years have explored the diagnostic and prognostic value of PC-MRI derived parameters. This review aims to identify all PC-MRI studies of iNPH published since 2010, synthesise a review based on collated results, and analyse specific flow parameters identified in the selected studies.
View Article and Find Full Text PDFArticle Synopsis
- CoRSIVs are regions in the genome with consistent DNA methylation patterns across tissues but show individual differences and are influenced by nearby genetic variants.
- This study focused on investigating SNPs within CoRSIVs and their potential link to pancreatic ductal adenocarcinoma (PDAC) risk, analyzing data from over 14,000 patients and 247,000 controls.
- The research identified that the A allele of SNP rs2976395 is linked to a higher risk of PDAC in Europeans and is associated with changes in DNA methylation and overexpression of the prostate stem cell antigen gene, highlighting the need for further functional studies.
Article Synopsis
- Brain arteriovenous malformations (AVMs) are complex vascular issues where arterial blood flows directly into veins, and the primary goal of treatment is to prevent bleeding.
- Advances in imaging and treatment techniques have improved safety and efficacy in managing AVMs, allowing for more personalized treatment plans.
- Treatment options include surgery, radiosurgery, endovascular embolization, and careful observation, with the need to balance risks and benefits for each individual patient.