Publications by authors named "P Silva-Bermudez"
In this work, we developed novel nanocomposite three-dimensional (3D) scaffolds composed of chitosan (CTS), halloysite nanotubes (HNTs) and silver nanoparticles (AgNPs) with enhanced antimicrobial activity and fibroblast cell compatibility for their potential use in wound dressing applications. A stock CTS-HNT solution was obtained by mixing water-dispersed HNTs with CTS aqueous-acid solution, and then, AgNPs, in different concentrations, were synthesized in the CTS-HNT solution a CTS-mediated reduction method. Finally, freeze-gelation was used to obtain CTS-HNT-AgNP 3D porous scaffolds (sponges).
View Article and Find Full Text PDFArticle Synopsis
- This study investigates how amorphous titanium oxide (aTiO) nano-coating can improve orthopedic implants made from materials like stainless steel (SS), focusing on enhancing strength, durability, and biocompatibility.
- The researchers used magnetron sputtering to apply aTiO coatings on SS, assessing their surface properties and biological interactions with human stem cells and macrophages while comparing them to both uncoated SS and treated titanium samples.
- Results showed that aTiO-coated SS promoted better bone cell differentiation, had anti-inflammatory effects similar to titanium, and significantly reduced bacterial growth, indicating that this coating could enhance the performance of non-titanium-based biomedical devices.
Insufficient osseointegration of titanium-based implants is a factor conditioning their long-term success. Therefore, different surface modifications, such as multifunctional oxide coatings, calcium phosphates, and the addition of molecules such as peptides, have been developed to improve the bioactivity of titanium-based biomaterials. In this work, we investigate the behavior of human oral mucosal stem cells (hOMSCs) cultured on amorphous titanium oxide (aTiO), surfaces designed to simulate titanium (Ti) surfaces, biofunctionalized with a novel sequence derived from cementum attachment protein (CAP-p15), exploring its impact on guiding hOMSCs towards an osteogenic phenotype.
View Article and Find Full Text PDFChitin is a structural polysaccharide abundant in the biosphere. Chitin possesses a highly ordered crystalline structure that makes its processing a challenge. In this study, chitin hydrogels and methanogels, prepared by dissolution in calcium chloride/methanol, were subjected to supercritical carbon dioxide (scCO) to produce porous materials for use as scaffolds for osteoblasts.
View Article and Find Full Text PDF