Publications by authors named "P Siironen"
The subtype of the papillary thyroid carcinoma tall-cell variant has a worse prognosis than does the conventional papillary type (papillary thyroid carcinoma). The new World Health Organization 2017 classification defines a tall-cell variant as a tumour consisting of over 30% of cells that are two or three times as tall as they are wide. However, thresholds have differed.
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- Total thyroidectomy is the main treatment for medullary thyroid carcinoma (MTC), but there's debate about how extensive neck dissection should be.
- A study of 54 patients treated at Helsinki University Hospital showed that 35% were disease-free after follow-up, while others had varying degrees of survival linked to factors like lymph node and distant metastases.
- Key findings reveal that lymph node metastasis and high postoperative calcitonin levels are strong indicators of prognosis, with advanced disease significantly impacting survival rates.
Article Synopsis
- Follicular thyroid lesions pose major challenges in cytopathology as it's hard to differentiate between benign adenomas and malignant carcinomas.
- A study investigated a new stem cell marker, HESC5:3, aimed at improving diagnosis by examining its expression in various thyroid lesions.
- Results showed significant differences in staining patterns between neoplastic and non-neoplastic lesions, suggesting that HESC5:3 could help distinguish between benign conditions like uninodular goitre and neoplasia, although it did not differentiate between adenomas and carcinomas.
Background: Well-differentiated follicular thyroid carcinomas (FTCs) usually act indolently, while aggressively acting tumors are difficult to detect early enough. Estrogen receptors (ERs) have prognostic significance in many cancers. Thyroid diseases, including neoplasms, are associated with the female sex.
View Article and Find Full Text PDFBackground: Well-differentiated follicular thyroid carcinoma usually has a favourable prognosis and metastases are rare. Toll-like receptors (TLRs) that take part in adaptive and innate immunity have, in many tumours, both apoptotic and antiapoptotic effects, making their role in tumourigenesis controversial. Chronic inflammation is involved in many cancers.
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