Publications by authors named "P Sienaert"
Prediction of electroconvulsive therapy outcome: A network analysis approach.
Acta Psychiatr Scand
November 2024
Article Synopsis
- Electroconvulsive therapy (ECT) is effective for major depressive disorder, but individual responses vary and are hard to predict due to differences in symptoms.
- The study analyzed data from 161 patients to determine which specific baseline depression symptoms could predict remission using a Mixed Graphical Model approach.
- Results showed that suicidality negatively predicted remission, while symptoms like psychomotor retardation and hypochondriasis were positively associated with better treatment outcomes.
The Global ECT MRI Research Collaboration (GEMRIC) has collected clinical and neuroimaging data of patients treated with electroconvulsive therapy (ECT) from around the world. Results to date have focused on neuroimaging correlates of antidepressant response. GEMRIC sites have also collected longitudinal cognitive data.
View Article and Find Full Text PDFLithium-associated hypercalcemia and hyperparathyroidism: A systematic review and meta-analysis.
World J Biol Psychiatry
October 2024
Objectives: We aimed to review and summarise the existing human literature on the association between lithium and hyperparathyroidism.
Methods: A systematic literature search was carried out according to PRISMA guidelines (last search 27 February 2024), using MEDLINE, Web of Science, Embase and the Cochrane Library. A meta-analysis was performed to determine the prevalence of lithium-associated hypercalcemia (LAH) in lithium-treated patients.
Posttraumatic stress disorder (PTSD) is associated with a high burden of disability and mortality. Despite standard treatments with antidepressants and/or psychotherapy, remission is often difficult to achieve. Electroconvulsive therapy (ECT) is an effective treatment for mood disorders but is currently not recognized as a treatment modality for PTSD.
View Article and Find Full Text PDFBackground: Increased gray matter volume (GMV) following electroconvulsive therapy (ECT) has been well-documented, with limited studies reporting a subsequent decrease in GMV afterwards.
Objective: This study characterized the reversion pattern of GMV after ECT and its association with clinical depression outcome, using multi-site triple time-point data from the Global ECT-MRI Research Collaboration (GEMRIC).
Methods: 86 subjects from the GEMRIC database were included, and GMV in 84 regions-of-interest (ROI) was obtained from automatic segmentation of T1 MRI images at three timepoints: pre-ECT (T), within one-week post-ECT (T), and one to six months post-ECT (T).