Effects of High Gamma Doses on the Structural Stability of Metal-Organic Frameworks.

Four different MOFs were exposed to γ rays by a cobalt-60 source reaching a maximum dose of 5 MGy. The results showed that the MIL-100 (Cr) and MIL-100 (Fe) did not exhibit obvious structural damage, suggesting their excellent radiation stability. MIL-101 (Cr) showed good radiation stability up to 4 MGy, but its structure started degrading with increasing radiation dose.

Modelling of the Lu/Lu radionuclide generator.

In order to determine the potential of Lu/Lu radionuclide generator in Lu production it is important to establish the technical needs that can lead to a clinically acceptable Lu product quality. In this work, a model that includes all the processes and the parameters affecting the performance of the Lu/Lu radionuclide generator has been developed. The model has been based on the use of a ligand to complex Lu ions, followed by the separation of the freed Lu ions.

Solid phase extraction-based separation of the nuclear isomers Lu and Lu.

A solid phase extraction based Lu-Lu separation method has been investigated for its feasibility to be used in the radionuclide generator. The use of 2,2',2"-(10-(2,6-dioxotetrahydro-2H-pyran-3-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid, (DOTAGA-anhydride) allowed grafting of DOTA (1,4,7,10-tetraazacyclododecane N,N',N″,N‴-tetraacetic acid) complex on the surface of commercially available amino propyl silica. The grafting of DOTA has been confirmed by several characterization techniques.

Cu-BTC Functional Microdevices as Smart Tools for Capture and Preconcentration of Nerve Agents.

Cu-based metal-organic framework (MOF) microdevices are applied in sampling and preconcentration of nerve agents (NAs) diluted in gaseous streams. An in situ electrochemical-assisted synthesis of a Cu-benzene-1,3,5-tricarboxylate (BTC) thick film is carried out to functionalize a Cu-modified glass substrate. This simple, rapid, reproducible, and easy-to-integrate MOF synthesis approach enables the microfabrication of functional micro-preconcentrators with a large Brunauer-Emmett-Teller (BET) surface area (above 2000 cm) and an active pore volume (above 90 nL) for the efficient adsorption of nerve agent molecules along the microfluidic channel 2.

Large-scale production of lutetium-177m for the Lu/Lu radionuclide generator.

In this work, Lu has been produced by irradiation of natural LuO targets at the BR2 reactor (Mol, Belgium) and the obtained data together with literature values have been used to theoretically investigate the production of Lu at different neutron fluxes, irradiation times and enrichment of Lu. The irradiation time (t) needed to reach the maximum Lu production has been found to change from 42, 12, 4 days with the increase in the thermal neutron flux from 2*10, 8*10, 2.5*10 n cm s, respectively while keeping the maximum Lu activity unaffected.