A Case of Complex Deformity of Knee Corrected by Ilizarov Fixation in a Teenage Patient.

Introduction: After the spine, the knee is the second most common location for skeletal tuberculosis. An unusual complication of tuberculosis infection is triple knee deformity. The combination of knee flexion, posterolateral tibial subluxation, and external tibial rotation over femoral condyles manifests as a severe deformity.

Music Therapy for Pain Management for People With Advanced Cancer: A Randomized Controlled Trial.

Objective: To improve mechanistic understanding, this randomized controlled trial examined anxiety, mood, emotional support, and pain-related self-efficacy as mediators of music therapy for pain management in people with advanced cancer.

Methods: People with advanced cancer who had chronic pain were randomized (1:1) to 6 weekly individual music therapy or social attention control sessions. We measured mediators and pain outcomes (pain interference and pain intensity) using self-report measures at baseline, session 4, and post-intervention.

Comprehensive river water quality monitoring using convolutional neural networks and gated recurrent units: A case study along the Vaigai River.

Effective monitoring of river water quality is required for long-term water resource management. Convolutional Neural Networks and Gated Recurrent Unit-based water quality monitoring (CNGRU-WQM) were used in this investigation to develop a comprehensive monitoring system along the Vaigai River. The system was designed to collect real-time data on several crucial water quality parameters.

A review on the pharmacology of cariprazine and its role in the treatment of negative symptoms of schizophrenia.

Management of negative symptoms is one of the most challenging and important unmet needs of schizophrenia treatment. Negative symptoms together with positive symptoms result in significant psychosocial impairment and poor quality of life. Existing studies on atypical antipsychotics reported limited treatment adherence due to higher prevalence of treatment-emergent adverse events, such as diabetes, weight gain, hyperlipidemia, hyperprolactinemia and hypertension.

C5aR1 signaling promotes region- and age-dependent synaptic pruning in models of Alzheimer's disease.

Introduction: Synaptic loss is a hallmark of Alzheimer's disease (AD) that correlates with cognitive decline in AD patients. Complement-mediated synaptic pruning has been associated with this excessive loss of synapses in AD. Here, we investigated the effect of C5aR1 inhibition on microglial and astroglial synaptic pruning in two mouse models of AD.