Publications by authors named "P Sean Van Zijl"
Brain ischemia is a major cause of neurological dysfunction and mortality worldwide. It occurs not only acutely, such as in acute ischemic stroke (AIS), but also in chronic conditions like cerebral small vessel disease (cSVD). Any other conditions resulting in brain hypoperfusion can also lead to ischemia.
View Article and Find Full Text PDFChemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has emerged as a powerful imaging technique sensitive to tissue molecular composition, pH, and metabolic processes in situ. CEST MRI uniquely probes the physical exchange of protons between water and specific molecules within tissues, providing a window into physiological phenomena that remain invisible to standard MRI. However, given the very low concentration (millimolar range) of CEST compounds, the effects measured are generally only on the order of a few percent of the water signal.
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- There is a growing need for non-invasive methods to monitor glycogen storage diseases (GSD), specifically utilizing saturation transfer (ST) MRI to observe changes in muscle glycogen in a GSD II mouse model.
- The research involved measuring various metabolites in the skeletal muscles of both healthy and GSD II mice at different ages, assessing the accumulation and levels of muscle glycogen and energy metabolites.
- Results showed that while glycogen accumulation increased in younger GSD II mice, it plateaued in adults, indicating potential biomarkers for monitoring disease progression and treatment efficacy in GSDs.
Article Synopsis
- Dynamic glucose enhanced (DGE) MRI, using techniques like CEST or CESL, aims to analyze glucose uptake but faces challenges with low sensitivity and motion artifacts.
- The new method proposed, called DS-DGE MRI, leverages linewidth broadening in water saturation spectra during glucose infusion to improve measurements.
- Initial tests on brain tumor patients show that DS-DGE MRI produces detailed area-under-the-curve maps that effectively highlight tumor regions, indicating its potential over existing imaging techniques.
The study aimed to investigate the feasibility of dynamic glucose-enhanced (DGE) MRI technology in the clinical application of glioma. Twenty patients with glioma were examined using a preoperative DGE-MRI protocol before clinical intervention. A brief hyperglycemic state was achieved by injecting 50 mL of 50% w/w D-glucose intravenously during the DGE imaging.
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