[Acute hemodynamic changes after nifedipine in older men with essential hypertension].

The authors selected from a group of 40 hypertonic patients 9 men (mean age 67 years, range 60-73 years) with reliably evaluated echocardiographic tracings without valvular defects and without impaired left ventricular kinetics. After two weeks on placebo every patients was given a single dose of 20 mg nifedipine. The echocardiographic examination, concurrently with a blood pressure reading, was made at the end of the placebo interval and 2.

Acute natriuretic effect of nifedipine in elderly males with essential hypertension.

Following a two-week placebo period a group of 10 elderly men (63-76 years) received a 20 mg nifedipine tablet each. Twelve hours later nifedipine, as compared to placebo, significantly raised diuresis, urine sodium excretion, and tubular sodium rejection, but had no effect on GFR and urine potassium excretion. A significant decrease in mean arterial BP was registered in the 6th hour following nifedipine.

[Acute natriuretic effect of nifedipine in elderly people with essential hypertension].

Following a two-week placebo period, a group of 10 elderly men (63-76 yrs) received a 20 mg nifedipine tablet each. Twelve hours later nifedipine, as compared to placebo, significantly raised diuresis, urine sodium excretion, and tubular sodium rejection, but had no affect GFR and urine potassium excretion. A significant drop in mean arterial pressure was registered six hours following nifedipine administration.

Nifedipine monotherapy in the hypertensive elderly: a placebo-controlled clinical trial.

A single-blind, placebo-controlled study was carried out to evaluate the suitability of slow-release nifedipine as antihypertensive monotherapy for the elderly. After a wash-out period, nifedipine slow-release tablets (20 mg twice daily) followed by matching placebo were administered, each for 4 weeks, to 23 patients over 60 years of age with essential mild to moderate hypertension. Nifedipine significantly reduced the systolic and diastolic blood pressure, and increased the pulse rate in both supine and upright positions.