Background: Colorectal carcinoma (CRC) is one of the most frequently diagnosed forms of cancer worldwide. The (, ) and genes encode proteins that are important therapeutic targets for the treatment of CRC and, together with the mismatch repair (MMR) system, are closely related to patient prognosis and survival in advanced CRC. Here we evaluate the mutational profile and the frequency of mutations in the , and genes, along with the expression of MMR in advanced CRC, at a tertiary hospital in southern Brazil.
View Article and Find Full Text PDFIn this episode of the Podcast Series on Training and Education, Pamela Schaefer, MD, joins host Monica Cheng, MD, to discuss incorporating education into radiology careers. Dr. Schaefer shares her journey, the role of leadership, and advice for aspiring educators.
View Article and Find Full Text PDFUrticaria and angioedema are caused by immunoglobulin E- and non-immunoglobulin E-mediated release of histamine and other inflammatory mediators from mast cells and basophils. Diagnosis is made clinically, and anaphylaxis must be ruled out if urticaria or angioedema is present. A limited nonspecific laboratory workup should be considered unless elements of the history or physical examination suggest specific underlying conditions.
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