Publications by authors named "P Scarpellini"
Article Synopsis
- Invasive fungal infections (IFIs) are a significant health issue for patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT), and Isavuconazole (ISA) is a safe antifungal treatment option being studied in combination with sirolimus.
- This retrospective analysis looked at 51 allo-HSCT patients treated with both ISA and sirolimus over about five years, focusing on the effectiveness, safety, and monitoring of drug levels.
- Results showed that ISA was effective in treating IFIs, with a 68% response rate after 90 days, and no significant drug interaction toxicities were reported when both drugs were administered at therapeutic levels.
Purpose: Cardiac implantable electronic device (CIED) infections are increasingly common. Gram-positive bacteria such as coagulase negative staphylococci and Staphylococcus aureus are the most commonly involved pathogens. The aim of this study was to describe the characteristics and outcome of patients with CIED infections who underwent device removal and were empirically treated with high dose (8-12 mg/kg daily) daptomycin (DAP) in combination with ceftriaxone (CRO).
View Article and Find Full Text PDFBackground: Cariprazine, a third-generation antipsychotic (TGAs), has demonstrated efficacy in the treatment of schizophrenia with good tolerability profile. Actual real-world literature data are lacking, particularly when exploring its efficacy in the long term. The present study examined the effects of cariprazine treatment on specific psychopathological domains with a particular focus on outcomes and side effects in real-life experience, after a long-term treatment.
View Article and Find Full Text PDFManagement of early-onset prosthetic joint infection: Case report and literature review.
J Clin Tuberc Other Mycobact Dis
May 2024
Article Synopsis
- - Nontuberculous mycobacteria are an uncommon but increasingly recognized cause of challenging infections in prosthetic joints, with only 17 documented cases in existing literature.
- - There are no established guidelines for treating these specific infections, making management difficult for healthcare providers.
- - The case of a 68-year-old woman with an early prosthetic joint infection is discussed, highlighting a successful tailored treatment approach and providing an overview of the available cases to help other physicians.