Publications by authors named "P Salgame"
In this prospective cohort of 2006 individuals with drug-susceptible tuberculosis in India, 18% had unfavorable treatment outcomes (4.7% treatment failure, 2.5% recurrent infection, 4.
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- Blood-based gene signatures for tuberculosis (TB) have potential for diagnosing the disease, but it's unclear if gene set enrichment analysis alone is enough for accurate predictions compared to original models.
- The study compared the performance of 19 TB gene signatures using various scoring methods across 24 datasets, evaluating how well these methods correlate with original trained models.
- Results showed that many gene scoring methods produced similar or better prediction accuracy for active TB compared to original models, supporting their use in predicting TB risk and treatment outcomes.
Malaria and tuberculosis remain highly prevalent infectious diseases and continue to cause significant burden worldwide. Endemic regions largely overlap, and co-infections are expected to occur frequently. Surprisingly, malaria-tuberculosis co-infection is relatively understudied.
View Article and Find Full Text PDFBackground: The evolution of tuberculosis (TB) disease during the clinical latency period remains incompletely understood.
Methods: 250 HIV-uninfected, adult household contacts of rifampicin-resistant TB with a negative symptom screen underwent baseline F-Fluorodeoxyglucose positron emission and computed tomography (PET/CT), repeated in 112 after 5-15 months. Following South African and WHO guidelines, participants did not receive preventive therapy.
Pulmonary tuberculosis is increasingly recognized as a risk factor for COPD. Severe lung function impairment has been reported in post-TB patients. Despite increasing evidence to support the association between TB and COPD, only a few studies describe the immunological basis of COPD among TB patients following successful treatment completion.
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