Publications by authors named "P Sahare"
Skin aging is characterized by progressive loss of functionality and regenerative potential of the skin, resulting in the appearance of wrinkles, irregular pigmentation, a decrease of elasticity, dryness, and rough texture. Damage to the skin caused by oxidative stress could substantially be slowed down by the use of phytochemicals that function as natural antioxidants. Although phytochemicals have immense potential as anti-aging medicines, their effectiveness as therapeutic agents is restricted by their poor solubility, biodistribution, stability, and hydrophilicity.
View Article and Find Full Text PDFRegenerative medicine is an innovative scientific field focused on repairing, replacing, or regenerating damaged tissues and organs to restore their normal functions. A central aspect of this research arena relies on the use of tissue-engineered scaffolds, which serve as structural supports that mimic the extracellular matrix, providing an environment that orchestrates cell growth and tissue formation. Remarkably, the therapeutic efficacy of these scaffolds can be improved by harnessing the properties of other molecules or compounds that have crucial roles in healing and regeneration pathways, such as phytochemicals, enzymes, transcription factors, and non-coding RNAs (ncRNAs).
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- Colorectal cancer (CRC) is a major global health issue, ranking as the third most diagnosed cancer in men and second in women, with high mortality rates.
- Natural compounds like curcumin and resveratrol show anticancer potential but face challenges in solubility and bioavailability, which can be improved using biogenic silica (BS) as a carrier.
- The study found that curcumin-resveratrol-loaded BS significantly reduced cell viability in CRC cell lines and affected important genes and signaling pathways, although further research and safety assessments are necessary before clinical application.
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- Antimicrobial resistance (AMR) is a major global public health issue, with forced migrants facing higher risks of infection and AMR during their journeys and in host countries.
- A study with 27 participants revealed that these migrants encountered poor living conditions, limited access to water, sanitation, and hygiene (WASH), and difficulties in accessing healthcare, exacerbating health problems like urinary and skin issues.
- The results emphasize the urgent need for coordinated interventions to improve healthcare access and mitigate AMR risks among migrant populations.
SrAlO:Eu in microcrystalline form was prepared by a combustion method. The formation of the material in a single phase was confirmed by XRD analysis. The material was crushed and sieved to get particles with different particle size ranges.
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