The ruthenium(II)-catalyzed regioselective annulation of -(7-azaindole)amides with 1,3-diynes has been demonstrated. Bioactive -amino-7-azaindole has been used as a new bidentate directing group to furnish an array of 3-alkynylated isoquinolones. Furthermore, the developed protocol works efficiently for both aryl- and heteroaryl-substituted amides producing a range of pharmacologically useful 7-azaindole-based isoquinolones with a wide range of functionality.
View Article and Find Full Text PDFA ruthenium(II)-catalyzed cross dehydrogenative annulation of -(7-azaindole)benzamides with maleimides has been demonstrated. Herein, we have explored the use of -amino-7-azaindole as a new bidentate directing group for dehydrogenative [4 + 2] annulation. This method works efficiently, affording a variety of pharmacologically useful 7-azaindole-based isoquinolones and showing a wide functional group tolerance.
View Article and Find Full Text PDFA new bimetallic MOF (BMOF) has been synthesized using iron and zinc as inorganic metal nodes and 1,4-benzenedicarboxylic acid (BDC) as the organic linker molecule. BMOF was confirmed by single-crystal X-ray diffraction (SCXRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy high-angle annular dark-field imaging (TEM-HAADF), field emission scanning electron microscopy energy-dispersive X-ray analysis (FESEM-EDX), vibrating sample magnetometry (VSM) and inductively coupled plasma mass spectrometry (ICP-MS) analysis. The synthesized BMOF shows excellent optical and magnetic properties.
View Article and Find Full Text PDFWe report a new application of -amino-7-azaindole as a new bidentate-directing group for [Ru(-cymene)Cl]-catalyzed C(sp)-H alkenylation/annulation of -(1-pyrrolo[2,3-]pyridin-1-yl)benzamides with internal alkynes to afford -isoquinolono-7-azaindole via the formation of C-C and C-N bonds. The reaction shows a wide range of substrate scope with different symmetrical and unsymmetrical alkynes, affording the desired product in good to excellent yields. In the case of unsymmetrical alkynes, a highly regioselective product was obtained, which was confirmed by single-crystal X-ray crystallography.
View Article and Find Full Text PDFThis work presents a novel approach of using natural plant leaf surfaces having intricate hierarchical structures as scaffolds for Pd nanoparticles and demonstrated it as a Green dip catalyst for Suzuki-Miyaura coupling reactions in water. The influence of the topographical texture of the plant leaves on the deposition and catalytic properties of Pd nanoparticles are presented and discussed. The catalytic activity can be correlated to the surface texture of the leaves, wherein it has been found that the micro/nanostructures present on the surface strongly influence the assembly and entrapment of the nanoparticles, and thereby control aggregation and leaching of the catalysts.
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