Publications by authors named "P Saeed"
Article Synopsis
- - Osteogenesis Imperfecta (OI), or "brittle bone disease," is a rare genetic disorder that causes fragile bones and potential deformities due to defects in collagen type I, requiring comprehensive care throughout a patient's life stages.
- - Treatment primarily focuses on supportive measures, including medications like bisphosphonates and various orthopedic surgeries, which have shown positive results, especially in children, but there is a notable lack of guidelines for adults transitioning from pediatric care.
- - A systematic review of existing literature emphasizes the need for a multifaceted approach by various medical specialists to enhance the transition from pediatric to adult care for OI patients, stressing the importance of education, personalized plans, and ongoing follow-up.
Treatment of isolated pediatric optic nerve glioma: A nationwide retrospective cohort study and systematic literature review on visual and radiological outcome.
Pediatr Blood Cancer
December 2024
Article Synopsis
- Progressive isolated optic nerve glioma (ONG) in children is a rare condition with no standard treatment consensus, and a study was conducted to compare the effectiveness of different treatment methods.
- The study involved 21 ONGs where systemic anticancer therapy (SAT) led to visual improvements in a significant number of cases, while surgery often resulted in worsening vision, and radiotherapy had mixed effects, including a potential increase in tumor volume shortly after treatment.
- The findings suggest that SAT is the preferred treatment for preserving vision, while surgery may help alleviate other symptoms in blind patients, but radiotherapy poses risks and needs careful evaluation before use.
Purpose: This review aims to discuss the psychological aspects of Graves' ophthalmopathy (GO), estimate the prevalence of depression and anxiety disorders in GO, examine whether these psychiatric disorders are more prevalent in GO than in Graves' disease (GD) without eye disease, and evaluate the main contributors for depression and anxiety in GO.
Methods: A review of the literature.
Results: Both depression and anxiety are associated with GO.
Determining Asymmetry Thresholds in Anophthalmia/Microphthalmia Using a Three-dimensional Animated Model.
Ophthalmic Plast Reconstr Surg
January 2025
Purpose: Congenital microphthalmia and anophthalmia are rare development disorders with underdevelopment of the orbital region, resulting in asymmetry of the face. No clear guidelines exist to determine when these deviations are acceptable.
Methods: The face of a healthy 6-year-old child was three-dimensionally scanned.
Purpose: To evaluate axial length (AL), orbital width (OW) and height (OH) development in congenital microphthalmia and anophthalmia (MICA) using serial ultrasonography measurements.
Methods: A longitudinal prospective cohort (n = 74) of unilaterally and bilaterally affected MICA patients was followed from 2013 to 2022 at the university hospital in Amsterdam, the Netherlands. Clinical entity, age, severity category based on axial length, conformer treatment and intra-orbital cysts were registered.