Publications by authors named "P Sa"

Objective: The primary goal of this article is to analyze whether there is still room for ovarian stimulation in poor responders prescribed the long protocol.

Methods: This retrospective cohort study analyzed the medical charts of patients seen at the Vida Centro de Fertilidade, a private fertility clinic in Rio de Janeiro, Brazil, from January 2018 to June 2023. It included poor responders described based on the Bologna criteria who were first prescribed conventional treatment with an antagonist protocol, without success, and then the long agonist protocol.

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Article Synopsis
  • - The study focused on evaluating the outcomes of arthroscopic single-bundle ACL reconstruction, highlighting its role in restoring knee stability after ACL tears, which can lead to joint changes if untreated.
  • - Conducted in Kolkata, India, the study involved 45 patients with a follow-up period of at least nine months, revealing that 93.34% had excellent to good recovery and a high average Lysholm knee score of 95.31.
  • - The findings concluded that this surgical technique using hamstring autograft is an effective treatment, allowing patients to return to their pre-injury activity levels without significant complications or long-term disabilities.
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The importance of boar reproductive traits, including semen quality, in the sustainability of pig production system is increasingly being acknowledged by academic and industrial sectors. Research is needed to understand the biology and genetic components underlying these traits so that they can be incorporated into selection schemes and managerial decisions. This article reviews our current understanding of genome biology and technologies for genome, transcriptome and epigenome analysis which now facilitate the identification of causal variants affecting phenotypes more than ever before.

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  • Cisplatin is a common chemotherapy treatment for advanced-stage oral squamous cell carcinoma (OSCC), but it can lead to the cancer coming back or spreading because cells can become resistant to it.
  • Scientists are investigating a substance called piperlongumine (PL) that could help make cancer cells more sensitive to cisplatin, but it has some challenges with being used as a medicine.
  • To make it work better, researchers created special nanoparticles (smart PL-NPs) that can deliver PL directly to cancer cells, helping to stop drug resistance and reduce tumor growth in models like mice and zebrafish.
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An 80-year-old woman who was an active smoker with neglected long-term hypertension, but no known previous aortic or connective tissue disorders, presented to the emergency department complaining of sudden chest pain associated with cardiogenic shock.

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