[Malignant lymphoma associated with angioedema].

The incidence of malignant lymphoma cases in constantly growing. Therefore it is worth-while to consider its presence even in cases where the symptoms do not give a clear indication of the disease. Two cases with angiooema being rare and not carachteristic signs for malignant lymphoma are reported.

[Cellular and molecular bases of allergic diseases of the conjunctiva].

The authors review the clinical signs of the five most frequent allergic diseases of the conjunctiva (seasonal allergic conjunctivitis, perennial allergic conjunctivitis, vernal conjunctivitis, atopic conjunctivitis and giant papillary conjunctivitis), and then the immunologic bases of the development of the early-type allergic reaction. In the course of this, they describe the roles played by IgE globulin and the mastocytes in histamine release, and also the possible effects manifested in allergic inflammation in consequence of the metabolic products of arachidonic acid formed in the cell membrane (leukotrienes, lipoxins, prostaglandins and thromboxanes). Following this, they present an account of the process by which the eosinophilic cells that play the main role in the later stages of allergic inflammation emerge from te vascular bed, and the effects of various adhesion molecules.

[Treatment of atopic dermatitis].

The authors give a survey of the treatment of atopic dermatitis with respect to its extent and severity. Our knowledge about the immunopathology of the disease altered during the past years and thus it was possible to use new medicines. The most important one among them is Cyclosporin A, which is a selective immunosuppressive drug.

[Immunopathologic disorders in atopic dermatitis].

The atopic dermatitis is a multifactorial inheritable disease, in which pathogenesis in addition to environmental factors (climate, allergens, clothing) genetically determined multiplex metabolic differences (arachidonic acids, essential fatty acids) and immunologic alterations play an important role. Within immunologic findings the disturbances of balance in Th1 and Th2 subclasses, the increased degranulation activity of mast cells and the increased antigen presentation activity of Langerhans cells can be stressed. The clinical immunological alterations shown in the diseases, the increased production of IgE and so the type I.