All roads lead to Rome: the plasticity of gut microbiome drives the extensive adaptation of the Yarkand toad-headed agama () to different altitudes.

The gut microbiome was involved in a variety of physiological processes and played a key role in host environmental adaptation. However, the mechanisms of their response to altitudinal environmental changes remain unclear. In this study, we used 16S rRNA sequencing and LC-MS metabolomics to investigate the changes in the gut microbiome and metabolism of the Yarkand toad-headed agama () at different altitudes (-80 m to 2000 m).

Oleanolic acid inhibits appetite through the TGR5/cAMP signaling pathway.

Inhibition of appetite is an effective approach to fight obesity. Recently, bile acids have been reported to suppress appetite and alleviate obesity via the Takeda G protein-coupled receptor 5 (TGR5). However, whether the downstream signaling molecule cyclic adenosine monophosphate (cAMP) of TGR5 is involved in this process remains unclear.

Barcoded screening identifies nanocarriers for protein delivery to kidney.

Targeted protein delivery with nanocarriers holds significant potential to enhance therapeutic outcomes by precisely directing proteins to specific organs or tissues. However, the complex interactions between nanocarriers and the biological environment pose considerable challenges in designing effective targeted delivery vehicles. In this study, we address this challenge by leveraging DNA-barcoded high-throughput screening.

Pyrimidine-based dual-target inhibitors targeting epidermal growth factor receptor for overcoming drug resistance in cancer therapy(2006-present).

The epidermal growth factor receptor (EGFR) is a pivotal member of the epidermal growth factor receptor family, exerting crucial regulatory influence on cellular physiological processes, particularly in relation to cell growth, proliferation, and differentiation. In recent years, numerous EGFR inhibitors have been introduced to the market; unfortunately, the effectiveness of single-target EGFR inhibitors has been compromised due to the development of drug resistance caused by EGFR mutations. Despite attempts by some researchers to address this issue through combination therapy with two or more drugs, instances of dose-limiting toxicities have been observed.

Relationship Between Intense Personal Celebrity Worship and Cosmetic Surgery Consideration Among Chinese Young Women: The Serial Mediating Effects of Body Dissatisfaction and Body Shame.

This study examined whether intense personal feelings toward celebrities are positively correlated with women's consideration of cosmetic surgery, and whether body dissatisfaction and body shame serve as possible mediators of this relationship. A sample of 605 Chinese female undergraduates completed questionnaires on celebrity worship, consideration of cosmetic surgery, body dissatisfaction, and body shame. The results revealed a significant positive correlation between intense personal feelings toward celebrities and the consideration of cosmetic surgery.