Tracking the correlation between spintronic structure and oxygen evolution reaction mechanism of cobalt-ruthenium-based electrocatalyst.

Regulating the spintronic structure of electrocatalysts can improve the oxygen evolution reaction performance efficiently. Nonetheless, the effects of tuning the spintronic structure for the oxygen evolution reaction mechanisms have rarely been discussed. Here, we show a ruthenium-cobalt-tin oxide with optimized spintronic structure due to the quantum spin interaction of Ru and Co.

Development of RT h-CLAT, a Rapid Assessment Method for Skin Sensitizers Using THP-1 Cells as a Biosensor.

In recent years, in vitro skin sensitization assays have been recommended as animal-free alternatives for the safety assessment of cosmetics and topical drugs, and these methods have been adopted in OECD test guidelines. However, existing assays remain complex and costly. To address this, we recently developed a more efficient, cost-effective, and accurate method for evaluating skin sensitizers by using immune cell-derived THP-1 cells as a biosensor, coupled with an RT-PCR-based assay.

SPP1+ macrophages promote head and neck squamous cell carcinoma progression by secreting TNF-α and IL-1β.

Background: Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease characterized by a heterogeneous tumor immune microenvironment (TIME). Tumor-associated macrophages (TAMs) constitute the major innate immune population in the TIME where they facilitate crucial regulatory processes that participate in malignant tumor progression. SPP1 + macrophages (SPP1 + Macs) are found in many cancers, but their effects on HNSCC remain unknown.

Precise Tuning of Flexoelectricity in SrTiO by Ion Irradiation.

Flexoelectric coefficient is a tetradic and its introduction enables centrosymmetric materials to exhibit piezoelectricity. However, the flexoelectric paradigm currently lacks a strategy to effectively tune the strain gradient for optimal electro-mechanical coupling. This study proposes a quantized collision model accessible through ionic irradiation technology to explore the flexoelectricity and precisely modulate the strain gradient.