Publications by authors named "P S Zeiner"
Background: Giant cell (gc)-enriched glioblastoma (gcGB) represents a distinct histological variant of isocitrate dehydrogenase wild-type adult-type glioblastoma with notable enlarged mono- or multinuclear tumor cells. While some studies suggest a survival advantage for gcGB patients, the underlying causes remain elusive. GcGBs are associated with TP53 mutations, and gcs were shown to accumulate DNA double-strand breaks and show deficient mitosis, potentially triggering cellular senescence programs.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the use of cell-free DNA (cfDNA) from cerebrospinal fluid (CSF) as a less invasive alternative to brain biopsies for diagnosing brain tumors and addressing tumor heterogeneity.
- A total of 33 CSF samples were collected from 30 patients, and shallow whole-genome sequencing was performed, revealing significant somatic copy number aberrations (SCNAs) in brain tumor patients' cfDNA.
- The findings suggest that cfDNA analysis can effectively identify relevant genomic alterations, offering insights into tumor evolution and heterogeneity, thus enhancing diagnostic accuracy for CNS cancers.
Article Synopsis
- Intragastric botulinum neurotoxin injections (IBNI) are being used as a weight-loss treatment, but an outbreak of severe iatrogenic botulism occurred in early 2023 in Europe after patients received this treatment in Turkey.
- A retrospective analysis was conducted on ten patients in Austria and Germany who experienced severe symptoms like double vision, swallowing difficulties, and paralysis after IBNI.
- Despite the severity of their conditions, all patients were hospitalized, many in intensive care, and ultimately recovered without lasting health issues, underscoring the need for awareness and risk mitigation in medical procedures involving botulinum neurotoxins.
Background: Maximum tumor resection improves overall survival (OS) in patients with glioblastoma. The extent of resection (EOR) is historically dichotomized. The RANO resect group recently proposed criteria for volumetry-based EOR assessment in patients that were treated according to Stupp´s protocol.
View Article and Find Full Text PDFObjective: Brain tumors and metastases account for approximately 10% of all status epilepticus (SE) cases. This study described the clinical characteristics, treatment, and short- and long-term outcomes of this population.
Methods: This retrospective, multi-center cohort study analyzed all brain tumor patients treated for SE at the university hospitals of Frankfurt and Marburg between 2011 and 2017.