Publications by authors named "P S Wellman"
Aims: This study explored the prospective use of the Ages and Stages Questionnaires-3 in follow-up after cardiac surgery.
Materials And Method: For children undergoing cardiac surgery at 5 United Kingdom centres, the Ages and Stages Questionnaires-3 were administered 6 months and 2 years later, with an outcome based on pre-defined cut-points: Red = 1 or more domain scores >2 standard deviations below the normative mean, Amber = 1 or more domain scores 1-2 standard deviations below the normal range based on the manual, Green = scores within the normal range based on the manual.
Results: From a cohort of 554 children <60 months old at surgery, 306 participated in the postoperative assessment: 117 (38.
Multisystem inflammatory syndrome in children (MIS-C) is a rare condition following SARS-CoV-2 infection associated with intestinal manifestations. Genetic predisposition, including inborn errors of the OAS-RNAseL pathway, has been reported. We sequenced 154 MIS-C patients and utilized a novel statistical framework of gene burden analysis, "burdenMC," which identified an enrichment for rare predicted-deleterious variants in BTNL8 (OR = 4.
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- Prolonged pleural effusion/chylothorax (PPE/C) is a complication in pediatric cardiac surgery that has not been thoroughly studied, prompting this investigation into its incidence, risk factors, and impact on outcomes.
- A multicentre study collected data on multiple post-operative complications across 5 UK hospitals, finding that PPE/C occurred in 6.5% of patients, typically 6 days after surgery, and increased mortality primarily in patients with multiple other complications.
- The study concludes that while PPE/C is associated with increased mortality, it does not significantly extend hospital length of stay in cases with multiple complications, highlighting the need for effective prevention and management strategies for PPE/C in complex post-operative care.
Severe febrile illnesses in children encompass life-threatening organ dysfunction caused by diverse pathogens and other severe inflammatory syndromes. A comparative approach to these illnesses may identify shared and distinct features of host immune dysfunction amenable to immunomodulation. Here, using immunophenotyping with mass cytometry and cell stimulation experiments, we illustrate trajectories of immune dysfunction in 74 children with multi-system inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2, 30 with bacterial infection, 16 with viral infection, 8 with Kawasaki disease, and 42 controls.
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