Publications by authors named "P S Vokonas"
Article Synopsis
- A study examined the link between solar and geomagnetic activity (SGA) parameters and levels of plasma B-complex vitamins, focusing on 910 participants over a span from 1998 to 2017.
- Researchers found that increases in certain SGA parameters, specifically interplanetary magnetic field (IMF) and sunspot number (SSN), were associated with lower levels of B vitamins and folate, particularly in individuals with higher B-complex supplementation.
- The study is notable for being the first to highlight the negative effects of solar activity on B vitamin and folate levels, suggesting potential health implications during times of heightened solar activity.
Earlier studies have revealed microRNAs (miRNAs) as potential biomarkers for neurological conditions, however, such evidence on psychiatric outcomes is limited. We utilized the Normative Aging Study (NAS) cohort to investigate the associations between extracellular miRNAs (ex-miRNA) and psychiatric symptoms among a group of older male adults, along with the targeted genes and biological pathways. We studied 569 participants with miRNA profile primarily measured in extracellular vesicles isolated from plasma, and psychiatric symptoms reported over 1996-2014 with repeated measures.
View Article and Find Full Text PDFBackground: Mechanistic studies of the effects of environmental risk factors have been exploring the potential role of microRNA(miRNAs) as a possible pathway to clinical disease. In this study we examine whether levels of toenail metals are associated with changes in extracellular miRNA(ex-miRNA) expression.
Methods: We used data derived from the Normative Aging Study from 1996 to 2014 to conduct our analyses.
Background: Space weather has been associated with increased risk of cardiovascular diseases in space and flight crew. However, limited research has focused on the ground population, particularly among the elderly who are vulnerable to aging-related diseases.
Objective: We evaluated the association between space weather alterations and biological aging using leukocyte telomere length as a biomarker in healthy elderly men.
Psychological stress remains an important risk factor for morbidity and mortality throughout the life course. However, there have been counterintuitive findings reported in previous studies of older persons that examine the relationships of perceived psychological stress with DNA methylation-based markers of aging, which also serve as predictors of morbidity and mortality (epigenetic age/clocks). We aimed to replicate and expand findings from existing work by examining relationships of self-reported stress with nine epigenetic clocks: Hannum, Horvath, Intrinsic, Extrinsic, SkinBloodClock, PhenoAge, GrimAge, DNAm Telomere Length, and Pace of Aging.
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