Publications by authors named "P S Shirley"

Article Synopsis
  • * The research aimed to combat neuroinflammation by targeting the NF-κB transcription factor and NLRP3 inflammasome protein using a new RNA-based treatment, SB_NI_112, which is safe and effectively penetrates the brain.
  • * Treatment with SB_NI_112 in prion-diseased mice resulted in reduced inflammation, preserved neurons, improved cognitive function, and increased lifespan, suggesting potential for similar applications in other neurodegenerative diseases, despite limitations in the study.
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Background: Endometrial carcinoma (EC) is increasing in incidence, attributed largely to the obesity epidemic. Ethnic differences in New Zealand have long been recognised, with Pacific women bearing the greater burden of disease. We hypothesise that the pooled national incidence rates underestimate the true burden of EC in our high-risk community.

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Purpose Of Review: The purpose of this review is to summarize the most recent up to date research data and recommendations regarding anaesthetic management of patients with liver disease undergoing surgery. The incidence of chronic liver disease (CLD) continues to rise and perioperative mortality and morbidity remains unacceptably high in this group. Meticulous preoperative assessment and carefully planned anaesthetic management are vital in improving outcomes in patients with liver disease undergoing surgery.

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Chelonitoxism is a type of seafood poisoning which usually occurs due to consumption of certain marine turtle flesh. As the pharmacology or chemistry of the toxin is still unknown, antidote or treatment to chelonitoxism is unavailable. The symptoms can vary from common gastro-intestinal symptoms to neurological manifestations and even death.

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