Publications by authors named "P S Sever"
Article Synopsis
- * The research showed that individuals with high polygenic risk scores have significantly higher blood pressure (almost 17 mmHg more) and over seven times the risk of developing hypertension compared to those with low scores.
- * Incorporating these genetic risk scores into hypertension prediction models improved their accuracy, and excitingly, similar genetic associations were found in a large African-American sample, underscoring the potential of these findings for precision health initiatives.
Article Synopsis
- Visit-to-visit systolic blood pressure variability (BPV) significantly predicts cardiovascular outcomes, highlighting the need for ongoing monitoring beyond just mean blood pressure control.
- A long-term study involving over 8,500 hypertensive participants examined the effects of BP control and variability across treatments with amlodipine and atenolol for up to 21 years.
- Findings revealed that while average systolic blood pressure is important, high BPV is an independent risk factor for cardiovascular events, even among patients with well-managed blood pressure.
Hypertension is the leading cause of death worldwide, affecting 1.4 billion people. Treatment options include the widely used calcium channel blockers, among which amlodipine, a dihydropyridine, has unique characteristics that distinguish it from other drugs within this class.
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- This study examines the relationship between resting heart rate and cardiovascular diseases, identifying 493 genetic variants linked to this trait through a large-scale analysis of 835,465 individuals.
- It highlights the significance of higher genetically predicted resting heart rates, which are associated with an increased risk of dilated cardiomyopathy but lower risk for conditions like atrial fibrillation and ischemic strokes.
- The study also challenges previous findings on resting heart rate and all-cause mortality, suggesting earlier results may have been influenced by biases, ultimately enhancing our understanding of the biological implications of resting heart rate in cardiovascular health.