Sex Differences in Natural History and Health Outcomes Among Individuals With Tic Disorders.

Objectives: To analyze sex differences in outcomes in Tourette syndrome (TS) and Persistent Motor or Vocal tic disorders (PMVT) in the Tourette Association of America International Consortium for Genetics (TAAICG) dataset.

Methods: The relationship between sex and clinical measures was explored in 2,403 participants (N = 2,109 with TS; N = 294 with PMVT) from the TAAICG dataset using generalized estimating equation regression models, and adjusted for age and family relationships.

Results: Female (vs male) participants with TS (25.

The Enzyme Effect: Broadening the Horizon of MS Optimization to Nontryptic Digestion in Proteomics.

In recent years, alternative enzymes with varied specificities have gained importance in MS-based bottom-up proteomics, offering orthogonal information about biological samples and advantages in certain applications. However, most mass spectrometric workflows are optimized for tryptic digests. This raises the questions of whether enzyme specificity impacts mass spectrometry and if current methods for nontryptic digests are suboptimal.

Neurobehavioral features in medication-overuse headache.

Background: Medication-overuse headache (MOH) has been related to the spectrum of dependence behavior and impaired orbitofrontal cortex function. Alexithymia is a trait comprising deficits in identifying self-emotions and perception. It was the aim of the study to investigate impulsivity and alexithymia, in patients with MOH and perform correlations with cerebral grey matter.

Nanoplasmonic Photoelectron Rescattering in the Multiphoton-Induced Emission Regime.

In strong-field laser-matter interactions, energetic electrons can be created by photoemission and a subsequent rescattering and can attain energy as much as 10 times the ponderomotive potential (U_{p}) of the laser field. Here, we show that with the unique combination of infrared laser sources (exploiting the quadratic scaling of U_{p}) and plasmonic nanoemitters (which enhance rescattering probability by orders of magnitude) ∼10U_{p} rescattered electrons can be observed in the multiphoton-induced regime. Our experiments correspond well to a model based on the time dependent Schrödinger equation and allowed us to reveal an unexpected aspect of ultrafast electron dynamics in the multiphoton emission regime.