Publications by authors named "P S Puri"

Article Synopsis
  • Over 768 million confirmed COVID-19 cases and 6.9 million deaths have been recorded globally by July 17, 2023, highlighting the devastating impact of the pandemic.
  • SARS-CoV-2, the virus responsible for COVID-19, has a complex structure, including a large RNA genome and an envelope that aids in its infectivity, although its exact origin remains unclear.
  • The review discusses various topics related to COVID-19, including its origins, implications for health and the economy, and a controversial link between SARS-CoV-2 and the enzyme aldose reductase, which could have implications for treatment and understanding of the virus's pathogenesis.
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Background: Due to demographic and epidemiological shifts, people are living until older ages with more morbidities. These morbidities often have shared pathophysiology, which leads to a rise in coexisting health issues known as 'multimorbidity'. Primary care studies and disease burden surveys have multiplied, unveiling varied aspects of multimorbidity, yet with inconsistent definitions and methods.

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Background: Preventing hepatic encephalopathy (HE) recurrence in cirrhosis, which is associated with an altered gut-liver-brain axis, is an unmet need. Fecal microbiota transplantation (FMT) is beneficial in phase-1 studies, but route and dose-related questions remain.

Methods: We performed a phase-2 randomized, placebo-controlled, double-blind, clinical trial of capsule and enema FMT in cirrhosis and HE on lactulose and rifaximin.

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Background: Sphingosine-1 phosphate (S1P) is a bioactive lipid molecule that modulates inflammation and hepatic lipid metabolism in MASLD, which affects 1 in 3 people and increases the risk of liver fibrosis and hepatic cancer. S1P can be generated by 2 isoforms of sphingosine kinase (SphK). SphK1 is well-studied in metabolic diseases.

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