Publications by authors named "P S Pine"
Glucagon-like peptide 1 receptor agonists modestly reduced low-density lipoprotein cholesterol and total cholesterol levels independent of weight reduction: a meta-analysis and meta-regression of placebo controlled randomized controlled trials.
Curr Med Res Opin
December 2024
Article Synopsis
- GLP-1 receptor agonists (GLP-1RAs) show a modest decrease in low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) based on a review of clinical trials.
- The analysis found no significant impact on triglycerides, very low-density lipoprotein cholesterol (VLDL-C), or high-density lipoprotein cholesterol (HDL-C).
- Weight changes did not have a notable effect on LDL-C or TC levels among study participants.
Background: Randomized controlled trials (RCTs) of glucagon-like peptide 1 receptor agonists (GLP-1RAs) form the basis for therapeutic recommendations for both males and females. Historically, females have been significantly underrepresented in RCTs.
Objectives: The authors sought to determine the trends of representation of females in GLP-1RA RCTs from 2007 to 2024.
Sex Disparity in the In-Hospital Outcomes of Patients with Kidney Disease Admitted for Myocardial Infarction: Insights from a Large National Database.
Cardiorenal Med
September 2024
Introduction: There is limited evidence as to the effect of sex on the outcomes of patients admitted for ST-elevation myocardial infarction (STEMI) who have a concomitant diagnosis of chronic kidney disease (CKD) and end-stage renal disease (ESRD). We aimed to determine if there are differences in the outcomes between males and females in these patient populations.
Methods: Data were obtained from the National Inpatient Sample database and patients were selected using the International Classification of Diseases, Ninth and Tenth Revision (ICD-9 and -10) codes.
Background: Semaglutide is increasingly used in the management of type 2 diabetes mellitus and obesity. Ensuring the safety of this medication is crucial for its clinical use. This meta-analysis evaluates the safety profile of semaglutide across patient populations and treatment durations.
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- - Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a serious complication after hematopoietic cell transplantation (HCT), and early treatment can improve patient outcomes, but diagnosis is difficult due to overlapping symptoms with other issues post-transplant.
- - The study aimed to validate "VODCheck," a biomarker-based test designed to predict VOD/SOS risk using three key biomarkers: hyaluronan (HA), angiopoietin-2 (ANG-2), and thrombomodulin (TM).
- - Results showed that VODCheck accurately predicted VOD/SOS risk at multiple time points post-HCT, demonstrating its effectiveness as an independent risk predictor and providing valuable insights for better