Publications by authors named "P S Oturai"
Abnormal uptake related to the thyroid gland on somatostatin receptor-targeted PET imaging: reported prevalence and rate of thyroid malignancy and parathyroid adenomas.
Sannia Mia Svenningsen Sjöstedt Christoffer Holst Hahn Åse Krogh Rasmussen Peter Sandor Oturai Per Karkov Cramon
Endocr Connect
December 2024
Article Synopsis
- Incidental uptake of tracers in or near the thyroid gland was found in a small percentage of patients undergoing specific PET scans for neuroendocrine neoplasms (NENs), raising questions about its significance.
- Out of 1808 patients, 42 showed abnormal thyroid uptake, with 5 diagnosed with thyroid malignancies and 13 suggesting possible parathyroid adenomas.
- The findings indicate a low overall prevalence but notable rates of malignancy and parathyroid conditions, highlighting the need for further studies to establish the best approaches for managing these incidental findings.
Article Synopsis
- The study investigates the relationship between adiponectin (ADP) levels, glucose metabolism, and body composition in adults with cystic fibrosis-related diabetes (CFRD).
- It was found that while ADP levels were negatively correlated with indicators of insulin resistance and lower body mass metrics, they did not show a correlation with glucose intolerance.
- The findings suggest that malnutrition in cystic fibrosis may contribute to elevated ADP levels, indicating a complex interaction between body composition and glucose metabolism in these patients.
Article Synopsis
- The study analyzes the use of Cu-DOTATATE PET/CT scans in managing neuroendocrine neoplasms, focusing on referral patterns and classifications based on established appropriate use criteria (AUC).
- A total of 1,290 patients underwent 2,249 scans, with the most common use being for monitoring without clinical progression (31.3%), followed by initial staging and restaging after surgery.
- The findings revealed varying outcomes, with a significant detection of disease progression solely on PET scans, indicating the need for updated guidelines for Cu-DOTATATE PET/CT usage.
Article Synopsis
- This study examined how age and body composition influence the accuracy of estimated glomerular filtration rate (eGFR) compared to measured glomerular filtration rate (mGFR) in heart transplant recipients.
- A total of 150 patients were analyzed, showing an initial weight gain and increase in mGFR during the first year after transplant, particularly in those under 45 years old.
- Results indicated that while eGFR was generally accurate, it significantly overestimated mGFR in younger patients, highlighting imprecision related to age rather than body composition.
Meta-[I]iodobenzylguanidine ([I]MIBG) scintigraphy with SPECT/CT is the standard of care for diagnosing and monitoring neuroblastoma. Replacing [I]MIBG with the new PET tracer meta-[F]fluorobenzylguanidine ([F]MFBG) and further improving sensitivity and reducing noise in a new long-axial-field-of-view (LAFOV) PET/CT scanner enable increased image quality and a faster acquisition time, allowing examinations to be performed without sedation or general anesthesia (GA). Focusing on feasibility, we present our first experience with [F]MFBG LAFOV PET/CT and compare it with [I]MIBG scintigraphy plus SPECT/CT for imaging in neuroblastoma in children.
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